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''Cronobacter'' is the officially recognised bacterial genus name for the organism which before 2007 was named ''Enterobacter sakazakii''. The name ''Enterobacter'' should no longer be used as the genus name as ''Cronobacter'' has been accepted in the ''International Journal of Systematic and Evolutionary Microbiology'', along with the description of the new species. . It is a Gram-negative, rod-shaped, pathogenic bacterium. The majority of ''Cronobacter'' cases are in adults, and additionally it is associated with a rare cause of invasive infection of infants with historically high case fatality rates (40–80%).〔 (Free full text )〕 In infants it can cause bacteraemia, meningitis and necrotising enterocolitis. Some neonatal ''C. sakazakii'' infections have been associated with the use of powdered infant formula〔〔 with some strains able to survive in a desiccated state for more than two years. However not all cases have been linked to contaminated infant formula. In November 2011, several shipments of Kotex tampons were recalled due to a ''Cronobacter'' (''E. sakazakii'') contamination.〔(【引用サイトリンク】 title=FDA Recall of Kotex Tampons )〕 All ''Cronobacter'' species, except ''C. condimenti'', have been linked retrospectively to clinical cases of infection in either adults or infants.. However multilocus sequence typing has shown that the majority of neonatal meningitis cases in the past 30 years, across 6 countries have been associated with only one genetic lineage of the species ''Cronobacter sakazakii'' called 'Sequence Type 4' or 'ST4', and therefore this clone appears to be of greatest concern with infant infections. The bacterium is ubiquitous being isolated from a range of environments and foods, and the majority of ''Cronobacter'' cases are in the adult population. However it is the association with intrinsically or extrinsically contaminated powdered formula which has attracted the main attention.According to multilocus sequence analysis (MLSA) the genus originated ~40 MYA, and the most clinically significant species, ''C. sakazakii'', was distinguishable ~15-23 MYA. .〔 〕 ==Taxonomy== ''E. sakazakii'' was defined as a species in 1980 by Farmer ''et al.''. DNA-DNA hybridization showed that ''E. sakazakii'' was 53–54% related to species in two different genera, ''Enterobacter'' and ''Citrobacter''. However, diverse biogroups within ''E. sakazakii'' were described and Farmer ''et al.'' suggested these may represent different species and required further research for clarification.〔 The taxonomic relationship between ''E. sakazakii'' strains has been studied using full-length 16S rRNA gene sequencing, DNA-DNA hybridization, multilocus sequence typing (MLST), f-AFLP, automated ribotyping. This resulted in the classification of ''E. sakazakii'' as a new genus, ''Cronobacter'' within the Enterobacteriaceae, initially comprising four named species in 2007. The taxonomy was expanded to five named species in 2008, and more recently (2011) to seven named species.〔〔〔 (Free full text )〕 The initial four named species in 2007 were ''Cronobacter sakazakii'' (comprising two subspecies), ''C. turicensis'', ''C. muytjensii'' and ''C. dublinensis'' (comprising three subspecies) plus an unnamed species referred to as ''Cronobacter'' genomospecies I. The taxonomy was revised in 2008 to include a fifth named species ''C. malonaticus'', which in 2007 had been regarded as a subspecies of ''C. sakazakii''. In 2012, ''Cronobacter'' genomospecies I was formally renamed ''Cronobacter universalis'', and a seventh species was described called ''Cronobacter condimenti''. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cronobacter sakazakii」の詳細全文を読む スポンサード リンク
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